The Inhale-Exhale Diet

In a study published in Cell Metabolism, chemical and biomolecular engineering professor James Liao, associate professor of human genetics and paediatrics Katrina Dipple, and their research team at UCLA showed that genetic alterations enable mice to convert fat into carbon dioxide and remain lean while eating the equivalent of a fast-food diet

Wii-Hab May Enhance Parkinson’s Treatment

The Nintendo Wii may help treat symptoms of Parkinson’s disease, including depression, a Medical College of Georgia researcher says. Parkinson’s disease is a degenerative disease that impairs motor skills. Dr Herz theorised that the popular computer game console, which simulates various sports and activities, could improve coordination, reflexes and other movement-related skills, but he found additional benefits as well

Blind to be Cured with Stem Cells

British scientists have developed the world’s first stem cell therapy to cure the most common cause of blindness. Surgeons predict it will become a routine, one-hour procedure that will be generally available in six or seven years’ time. The treatment involves replacing a layer of degenerated cells with new ones created from embryonic stem cells. It was pioneered by scientists and surgeons from the Institute of Ophthalmology at University College London and Moorfields eye hospital

Fixing a Genetic Flaw

An international team of researchers has successfully treated dogs with the canine form of Duchenne muscular dystrophy (DMD), a rapidly progressing and ultimately fatal muscle disease that afflicts one out of every 3,600 boys. The researchers used a novel technique called exon skipping to restore partial function to the gene involved in Duchenne. The study, published in Annals of Neurology, gives hope that a similar approach could work in humans

British Scientists to Create Synthetic Blood

Scientists in Britain plan to become the first in the world to produce unlimited amounts of synthetic human blood from embryonic stem cells for emergency infection-free transfusions. A major research project is to be announced this week that will culminate in three years with the first transfusions into human volunteers of synthetic blood made from the stem cells of spare IVF embryos. It could help to save the lives of anyone from victims of traffic accidents to soldiers on a battlefield by revolutionising the vital blood transfusion services, which have to rely on a network of human donors to provide a constant supply of fresh blood

‘Brain Decline’ Begins at age 27

Mental powers start to dwindle at 27 after peaking at 22, marking the start of old age, US research suggests. Professor Timothy Salthouse of the University of Virginia found reasoning, spatial visualisation and speed of thought all decline in our late 20s. Therapies designed to stall or reverse the ageing process may need to start much earlier, he said. His seven-year study of 2,000 healthy people aged 18-60 is published in the journal Neurobiology of Aging

Thumbs Up for 3D Bone Printer

Exact replicas of a man’s thumb bones have been made for the first time using a 3D printer. The breakthrough paves the way for surgeons to replace damaged or diseased bones with identical copies built from the patients’ own cells. In theory, you could do any bone, says Christian Weinand of the Insel Hospital in Berne, Switzerland, head of the team that copied his thumb bones. Now I can put spares in my pocket if I want, he says

Bionic Eye Gives Blind Man Sight

A man who lost his sight 30 years ago says he can now see flashes of light after being fitted with a bionic eye. Ron, 73, had the experimental surgery seven months ago at London’s Moorfield’s eye hospital. He says he can now follow white lines on the road, and even sort socks, using the bionic eye, known as Argus II. It uses a camera and video processor mounted on sunglasses to send captured images wirelessly to a tiny receiver on the outside of the eye

Canadian Stem Cell Breakthrough

The ethical debate over embryonic stem cell use may soon be moot, thanks to a Canadian team of researchers who, together with a team out of Scotland, has found a safe way to grow stem cells from a patient’s own skin. The revolutionary finding, described in a paper published yesterday by the international science journal Nature, means doctors may be one step closer to treating a multitude of diseases, including Alzheimer’s, diabetes and Parkinson’s

Antibodies Offer a New Path for Fighting Flu

In a discovery that could radically change how the world fights influenza, researchers have engineered antibodies that protect against many strains of the virus, including even the 1918 Spanish flu and the H5N1 bird flu. The discovery, experts said, could lead to the development of a flu vaccine that would not have to be changed yearly. And the antibodies already developed can be injected as a treatment, going after the virus in ways that drugs like Tamiflu do not

HIV Gene Therapy Trial Promising

One of the first attempts to use gene therapy to treat HIV has produced promising results in clinical trials. When the therapy was tested on 74 patients, it was shown to be safe and appeared to reduce the effect of the virus on the immune system. In theory, one treatment should be enough to replace the need for a lifetime of antiretroviral therapy

Sponge’s Secret Weapon Restores Antibiotics’ Power

A chemical from an ocean-dwelling sponge can reprogram antibiotic resistant bacteria to make them vulnerable to medicines again, new evidence suggests. Ineffective antibiotics become lethal once again for bacteria treated with the sponge compound, chemist Peter Moeller reported 13 February at the American Association for the Advancement of Science annual meeting

Edible Technology Relays Medical Data from Inside the Body

Proteus Biomedicals, a company in California, has developed an intelligent pill that sends digital signals to an external receiver after being swallowed. The pill still works as an ordinary drug that a patient might take to control a health issue such as heart trouble or a psychiatric disorder. But it also has digestible sensors that are made of food products and are activated by stomach fluids. Once swallowed, the sensors can send a digital signal through the body to a receiver. The receiver date- and time-stamps, decodes, and records information about the drug and the dosage. It also measures and reports heart rate, activity, and respiratory rate

Implant Raises Cellular Army to Attack Cancer

Implants that sit in the body and reprogram a person’s immune cells could be used to treat a range of infectious diseases and even cancer. In a trial on mice with an aggressive melanoma that usually kills within 25 days, the new treatment saved 90% of the group. Because cancer cells originate within the body, the immune system usually leaves them alone. Therapies exist that involve removing immune cells from the body before priming them to attack malignant tissue and injecting them back into a patient

A Moment Of Tooth

Regenerating a whole tooth is no less complicated than rebuilding a whole heart, says Songtao Shi of the University of Southern California, who heads a team working on creating such a tooth. Not only do you have to create smart tissue (nerves), strong tissue (ligaments) and soft tissue (pulp), you’ve got to build enamel — by far the hardest structural element in the body. And you have to have openings for blood vessels and nerves. And you have to make the whole thing stick together. And you have to anchor it in bone. And then you have to make the entire arrangement last a lifetime in the juicy stew of bacteria that is your mouth. It’s a nuisance, but researchers are closing in on it. In fact, they think the tooth will probably be the first complex organ to be completely regenerated from stem cells. In part this is because teeth are easily accessible — say ahhhhh. So are adult stem cells, found abundantly in both wisdom and baby teeth — no embryos required, and your immune system won’t reject your own cells