Health, Science

Alzheimer’s treatment breakthrough: British scientists pave way for simple pill to cure disease

Scientists have hailed an historic turning point in the search for a medicine that could beat Alzheimer’s disease, after a drug-like compound was used to halt brain cell death in mice for the first time.

Although the prospect of a pill for Alzheimer’s remains a long way off, the landmark British study provides a major new pathway for future drug treatments.

The compound works by blocking a faulty signal in brains affected by neurodegenerative diseases, which shuts down the production of essential proteins, leading to brain cells being unprotected and dying off.

It was tested in mice with prion disease — the best animal model of human neurodegenerative disorders – but scientists said they were confident the same principles would apply in a human brain with debilitating brain diseases such as Alzheimer’s or Parkinson’s.

The study, published today in the journal Science Translational Medicine, was carried out at the Medical Research Council’s (MRC) Toxicology Unit at the University of Leicester — via redwolf.newsvine.com

Technology

Why Microsoft Word must Die

I hate Microsoft Word. I want Microsoft Word to die. I hate Microsoft Word with a burning, fiery passion. I hate Microsoft Word the way Winston Smith hated Big Brother. Our reasons are, alarmingly, not dissimilar …

Microsoft Word is a tyrant of the imagination, a petty, unimaginative, inconsistent dictator that is ill-suited to any creative writer’s use. Worse: it is a near-monopolist, dominating the word processing field. Its pervasive near-monopoly status has brainwashed software developers to such an extent that few can imagine a word processing tool that exists as anything other than as a shallow imitation of the Redmond Behemoth. But what exactly is wrong with it? — via redwolf.newsvine.com

Craft, Wildlife

Bead Embroidered Deathshead Hawkmoth / beadedmischka

This brooch I made of beaded embroidery technique. Embroidery is on the base (Lacy’s Stiff Stuff), were used Japanese TOHO beads nad Miyuki Delica in grey, gold, beige and black colours. Death’s-head is the skull of glass. Lined in Alcantara — via Etsy

Technology

Australian universities create ‘photons on demand’ optical chip

Research conducted at the University of Sydney has delivered photonic chips that slow down light, creating the ability to produce a single photon of light with increased reliability, which allows for more scalable and smaller optical hardware.

The research is published in the Nature Communications journal, with the team responsible made up of members from Macquarie University, the University of St Andrews, the University of York, and the Australian Research Council Centre of Excellence for Ultrahigh Bandwidth Devices for Optical Systems (CUDOS) based at the University of Sydney, as well as the Australian Defence Science and Technology Organisation (DSTO).

It is easy for us to generate photons at high rates, but it’s much harder to ensure they come out one by one, because photons are gregarious by nature and love to bunch together, said lead author of the research article Matthew Collins, a PhD student at CUDOS.

For that reason, the quantum science community has been waiting over a decade for a compact optical chip that delivers exactly one photon at a time at very high rates — via redwolf.newsvine.com

Craft, Wildlife

Baby Cephalopods / June Gilbank

Four original crochet amigurumi patterns: Octopus, Squid, Cuttlefish and Nautilus — the complete Baby Cephalopods collection by June Gilbank. These mini amigurumi take only 25-30m of yarn apiece, and work up quickly with minimal finishing, as they only have 2-3 pieces each — via Etsy

Art, Wildlife

Alligators / Paul Eppling

Paul Eppling is a St Petersburg sculptor, well known in Florida for his metallic animals. According to blogger Mark Ruffner, Paul Eppling was working in a metal shop in the 1970s when he first had the idea to fabricate an animal from metal parts and scraps. Since then he’s welded hundreds of animals, big and small — via What The Wig?

Craft, Wildlife

Dragon mittens / HotScones

These fabulous aubergine (eggplant) colour dragon, dinosaur or monster fingerless mittens will fit a medium female adult hand and are made from 75% wool, 15% mohair, 5% alpaca, 5% silk. They were designed and handmade in the tropical north of Australia and are ready to ship — via Etsy

Business, Rights, Technology

Palantir Technologies defence contracts in Canberra

On the fourth floor of an office building on Northbourne Avenue, in what passes for Canberra’s CBD, is an outpost of a much talked-about company that has so far gone under the radar in Australia. It is, however, unlikely that many Australians have avoided the company’s forensic gaze.

Palantir Technologies was established in 2002 by a clutch of US information analysts to explore the potential of datamining tools developed for Paypal. The CIA was a foundation investor, providing $2 million, and for several years its only customer. However, unusually for a company that has become a key vendor to the US military-industrial complex, its senior ranks are almost entirely men (and they’re pretty much all men) with Silicon Valley-style IT or financial backgrounds; the revolving door to the US military and foreign policy establishments that typifies most defence and intelligence companies doesn’t appear to be in full operation (yet).

Palantir does datamining, and does it very, very well. So well, in fact, that the US government and major companies have hungrily devoured its data search tools (for an account of what exactly its products can do, try this). As we’ve since learnt courtesy of Edward Snowden, agencies like the NSA are compiling vast amounts of personal information on most of the planet’s internet users. Palantir’s products help agencies effectively search through huge amounts of different information and collate them with other agencies’ data. It has rapidly become a key player in the establishment of the US surveillance state and a poster boy for what smart people and lots of computing power can do to strip away privacy and garner intelligence down to the individual level. And it has rapidly become an attractive investment: two weeks ago the company, now estimated to be worth $8 billion, announced it had raised nearly $200 million in capital.

And behind a unicorns-and-rainbows façade (Palantir is a Lord of the Rings reference; its California headquarters is called the Shire) is a ruthless player in cybersecurity. In 2011, as Crikey reported at the time, the company joined with Berico Technologies and HBGary Federal to develop a multi-million dollar plant to disrupt WikiLeaks and discredit journalist Glenn Greenwald. The plan, only revealed when Anonymous hacked into the IT system of HBGary Federal’s Aaron Barr, involved proposals to feed false information to WikiLeaks, break into its servers and wage a media campaign against it and Greenwald — via redwolf.newsvine.com

Art, Wildlife

Octopus Mug / sewZinski

This black ceramic mug with white interior has a hand painted pink octopus with wiggly tentacled arms and a wide staring eye — via Etsy

Politics, Rights, Technology, World

The most embarrassing news interview ever

This must be the most cringe-inducing interview by a senior journalist I’ve ever seen.

It’s conducted by Kirsty Wark, one of the BBC’s top presenters, and takes places on Newsnight, the BBC’s flagship nightly current affairs programme.

It truly makes me more ashamed of the profession of journalism than I already was — and I didn’t think that was possible.

Throughout the interview, Wark abandons even the pretence of doing what journalism is supposed to be about: interrogating the centres of power and holding them to account.

Instead Wark mimics adversarial journalism by interrogating the US journalist Glenn Greenwald about his role in the NSA leaks, as though she’s a novice MI5 recruit. To do this she has to parrot British government misinformation and fire at him questions so childish even she seems to realise half way through them how embarrassing they are — via redwolf.newsvine.com

World

Obituary: Mark ‘Chopper’ Read

One of Australia’s most notorious standover men and self-confessed hit-man Mark Chopper Read has died.

The 58-year-old had been diagnosed with liver cancer last year.

Read claimed to have killed 19 men, but he was never convicted of a single murder.

Following a hard upbringing in Melbourne, Read was a ward of the state by his early teens.

He turned to a life of crime, stealing from drug dealers, and later kidnapping and assaulting criminals who had outstanding debts.

In 1987 he shot and killed a man outside a St Kilda nightclub but was acquitted on the grounds of self-defence.

Read spent nearly half his life in jail but made efforts to rehabilitate after he was released from a Tasmanian prison in the 1990s.

He became a household name in Australia after the eponymous film Chopper, starring Eric Bana, became a cult hit — via redwolf.newsvine.com

Photo: Patrick Rivere / Getty Images

Wildlife

Jaguar Cub, Sasha / Fort Worth Zoo

Yesterday, Fort Worth Zoo in Texas announced the birth of the zoo’s newest resident: a female Jaguar cub. The healthy cub, named Sasha, was born 16 July and weighed 0.9 kg. Sasha immediately began nursing and bonding with 4-year-old mother Xochi (zo-she). Xochi is a very protective mother; after giving birth, she cared for her cub in a private, off-exhibit area, mimicking natural Jaguar behaviour in the wild — via ZooBorns

Craft

Siebel Cabinet / AERO-1946

AERO-1946 is a studio in Cologne, Germany. For six years, its two craftsmen have made household and workshop furniture pieces inspired by 1940s-era aviation. It often incorporates vintage remains of planes into the work.

The craftsmen made this lovely upright cabinet using the door of a Siebel Si 204, a German military and civilian transport in production from during World War II. The door sat in the basement of a home in eastern Germany for 70 years. AERO-1946 rebuilt it and fixed it into a shiny new cabinet body. The entire project took about 600 hours of work — via Neatorama

Entertainment

BBC to reveal a number of missing Doctor Who episodes

A number of early episodes of Doctor Who, which were believed to have been permanently lost, have been returned to the BBC.

BBC Worldwide is expected to confirm the find at a press screening in London later this week.

It follows weeks of speculation that some lost episodes had been located.

A total of 106 episodes featuring the first two actors to play the Doctor, William Hartnell and Patrick Troughton, are currently missing.

The BBC destroyed many of the sci-fi drama’s original transmission tapes in the 1960s and 1970s.

However, the majority of the episodes had been transferred on to film for foreign broadcasters. It is often these prints found in other countries that are the source of retrieved episodes — via redwolf.newsvine.com

Craft, Entertainment, Wildlife

Applejack and Pinkie Pie / morisato54

What do you get when you put Applejack and Pinkie Pie in one automaton? I’m not really sure myself, but it certainly looks like a lot of fun! WOOOOO!!! Both ponies, stand, apples, balloons and trophy body are carved from Philippine mahogany. The gears and trophy figurehead are made of Narra hardwood. The figures are hand painted with enamel and protected with clear flat lacquer. Both ponies stand at 5″ and the whole piece measures 8 1/2″ long, 5″ wide, and 7 3/4″ high. It took 124 hours to make — via Youtube