The Lives They Lived: Uneasy Rider

Mike DeStefano was still on the rise as a comedian when he died of a heart attack at 44. He was one of the finalists on NBC’s Last Comic Standing; and definitely stood out from the pack. He wasn’t always the funniest, but there was something direct and heartfelt about him that made you root for him, and you could feel the weight of his personal story, always. He grew up tough in the Bronx. Had been addicted to heroin. Three months before his death, he spoke with his fellow comedian Marc Maron on the WTF podcast. With permission from DeStefano’s family, we’ve edited and condensed the interview and replaced the words that can’t be printed in a family newspaper.

DeStefano: She’s holding the pole! Marc, it was a pole with four wheels on the bottom, and we’re riding around this hospice, and you could hear the god damn wheels jangling and banging; it was insane.

And then I pass the front door, and all these nurses are standing out front, and they’re all crying. They’re watching us, and they’re crying. And I didn’t know why they were crying. I was like, Why are they crying? I didn’t get what they were seeing. I didn’t know. Because I was just in it; I was living it. I knew my wife who had suffered, she was a prostitute, she was a freakin’ heroin addict, she was beaten by pimps — this was her past — and then she ends up with AIDS, and she’s dying, and all she wants is a god damn ride on my motorcycle.

So the next thing you know we’re on I-95, because women, it’s never enough for them. We’re on I-95, and she unhooks the pole, and she’s holding the morphine bag over her head with her gown that’s flying up in the air so you could see her entire naked, bony body with the morphine bag whipping in the wind, and we’re passing by these guys in their Lamborghinis, and I’m looking at them like, What the hell kind of life are you living? Look at me, I’m on top of the world here — via redwolf.newsvine.com

Stem cells may aid vision in blind people

Two legally blind women appeared to gain some vision after receiving an experimental treatment using embryonic stem cells, scientists have reported.

Last year, each patient was injected in one eye with cells derived from embryonic stem cells at the University of California, Los Angeles. One patient had the dry form of age-related macular degeneration, the most common cause of blindness. The other had a rare disorder known as Stargardt disease that causes serious vision loss. There’s no cure for either eye problem.

After four months, both showed some improvement in reading progressively smaller letters on an eye chart. The Stargardt patient, a graphic artist in Los Angeles, went from seeing no letters at all to being able to read five of the largest letters — via redwolf.newsvine.com

Cosmetic surgeons call for surgery adverts ban

Cosmetic surgery advertising should be banned and annual checks carried out on surgeons, the industry has said.

The British Association of Aesthetic Plastic Surgeons (BAAPS) wants measures including increased regulation of the cowboy market in the UK.

Prof Sir Bruce Keogh is leading a government review of the trade after the PIP breast implants scandal.

Sir Bruce has said an insurance scheme for the sector, similar to that in the travel industry, could be introduced — via redwolf.newsvine.com

Dangerous abortions on the rise, says WHO

A rising proportion of abortions worldwide are putting women’s health at risk, researchers say.

The World Health Organisation study suggests global abortion rates are steady, at 28 per 1,000 women a year.

However, the proportion of the total carried out without trained clinical help rose from 44% in 1995 to 49% in 2008.

The Lancet, which carried the report, said the figures were deeply disturbing.

Unsafe abortion is one of the main contributors to maternal death worldwide, and refers to procedures outside hospitals, clinics and surgeries, or without qualified medical supervision.

Women are more vulnerable to dangerous infection or bleeding in these environment — via redwolf.newsvine.com

North Carolina Sets $50K Compensation for Victims of Eugenics Program

A task force assigned to the grim undertaking of deciding how much to compensate as many as 2,000 living victims of a decades-long North Carolina sterilisation program finally settled on a number on Tuesday.

Each person who was forced to undergo surgical procedures to render them incapable of reproduction under the state’s notorious eugenics programs should receive $50,000, the Governor’s Task Force to Determine the Method of Compensation for Victims of North Carolina’s Eugenics Board announce — via redwolf.newsvine.com

Nursing’s modern day miracle workers doing it tough

Welcome to the world of the Brown Nurses, an intriguing benevolent organisation unknown to most except those who require its services.

For almost 100 years, this unsung group of volunteers, sisters and registered nurses have gone about doing the work inspired by someone whom many Catholics consider to be a Sydney saint-in-waiting.

Based in Glebe, Coogee, Minto and Newcastle, they provide health, welfare and advocacy services to severely marginalised individuals and families.

Many of their clients are suffering the debilitating effects of mental illness, physical disability, chronic addictions or a combination of all three. Being on the Brown Nurses’ books is their last chance to live independently — via redwolf.newsvine.com

Bereavement raises heart attack risk, says study

The newly bereaved are at greatly increased risk of heart attack after the death of a close loved one, US researchers say.

Heart attack risk is 21 times higher within the first day and six times higher than normal within the first week, a study in the Circulation journal of nearly 2,000 people shows.

Symptoms to watch for include chest pain and shortness of breath.

Experts say intense grief puts extra strain on the heart — via redwolf.newsvine.com

How Doctors Die

Years ago, Charlie, a highly respected orthopaedist and a mentor of mine, found a lump in his stomach. He had a surgeon explore the area, and the diagnosis was pancreatic cancer. This surgeon was one of the best in the country. He had even invented a new procedure for this exact cancer that could triple a patient’s five-year-survival odds — from 5 percent to 15 percent — albeit with a poor quality of life. Charlie was uninterested. He went home the next day, closed his practice, and never set foot in a hospital again. He focused on spending time with family and feeling as good as possible. Several months later, he died at home. He got no chemotherapy, radiation, or surgical treatment. Medicare didn’t spend much on him.

It’s not a frequent topic of discussion, but doctors die, too. And they don’t die like the rest of us. What’s unusual about them is not how much treatment they get compared to most Americans, but how little. For all the time they spend fending off the deaths of others, they tend to be fairly serene when faced with death themselves. They know exactly what is going to happen, they know the choices, and they generally have access to any sort of medical care they could want. But they go gently.

Of course, doctors don’t want to die; they want to live. But they know enough about modern medicine to know its limits. And they know enough about death to know what all people fear most: dying in pain, and dying alone. They’ve talked about this with their families. They want to be sure, when the time comes, that no heroic measures will happen — that they will never experience, during their last moments on earth, someone breaking their ribs in an attempt to resuscitate them with CPR (that’s what happens if CPR is done right).

Almost all medical professionals have seen what we call futile care being performed on people. That’s when doctors bring the cutting edge of technology to bear on a grievously ill person near the end of life. The patient will get cut open, perforated with tubes, hooked up to machines, and assaulted with drugs. All of this occurs in the Intensive Care Unit at a cost of tens of thousands of dollars a day. What it buys is misery we would not inflict on a terrorist. I cannot count the number of times fellow physicians have told me, in words that vary only slightly, Promise me if you find me like this that you’ll kill me. They mean it. Some medical personnel wear medallions stamped NO CODE to tell physicians not to perform CPR on them. I have even seen it as a tattoo — via redwolf.newsvine.com

Hard and Fast Hands-Only CPR / Vinnie Jones

Vinnie Jones shows how hard and fast hands-only CPR to Stayin’ Alive by the Bee Gees can help save the life of someone who has had a cardiac arrest. The Hollywood hardman is starring in a British Heart Foundation TV advert urging more people to carry out CPR in a medical emergency

Virus theory for chronic fatigue dismissed

The latest theory that chronic fatigue syndrome is caused by a virus has been killed off.

It is just two years since researchers gave hope to sufferers that a cure may be on the horizon.

Just before Christmas two of the global giants of science publishing from the United United States, Science and Proceedings of the National Academy of Science, withdrew published papers which claimed sufferers carried a virus — via redwolf.newsvine.com

Hepatitis C vaccine: Oxford researchers’ trial ‘promising’

An early clinical trial of a hepatitis C vaccine has shown promising results, according to researchers at Oxford University.

Designing a vaccine has been difficult as the virus changes its appearance, making it hard to find something to target.

Writing in Science Translational Medicine, researchers say their trial on 41 patients shows it is possible.

The Hepatitis C Trust said the findings were very promising — via redwolf.newsvine.com

Scientists unveil first MS stem cell model

Australian researchers have developed the world’s first stem cell model of multiple sclerosis, opening up new ways to study the disease and test treatments.

The deputy director of Monash University’s immunology and stem cell laboratory, Claude Bernard, said he and his colleagues had used skin cells from MS sufferers to create induced pluripotent stem cells that have the capacity to become brain cells targeted by the disease.

This effectively creates a disease in a dish that can be replicated and studied by researchers who have previously had only blood cells, autopsy tissue and cerebrospinal fluid to work on. The cells also mean scientists can avoid using human embryos, overcoming ethical concerns.

Professor Bernard said this would create a limitless supply of the cells for researchers to study the mechanisms of the disease and to test new drugs — via redwolf.newsvine.com

Led by the child who simply knew

Jonas and Wyatt Maines were born identical twins, but from the start each had a distinct personality.

Jonas was all boy. He loved Spiderman, action figures, pirates, and swords.

Wyatt favored pink tutus and beads. At 4, he insisted on a Barbie birthday cake and had a thing for mermaids. On Halloween, Jonas was Buzz Lightyear. Wyatt wanted to be a princess; his mother compromised on a prince costume.

Once, when Wyatt appeared in a sequin shirt and his mother’s heels, his father said: You don’t want to wear that.

Yes, I do, Wyatt replied.

Dad, you might as well face it, Wayne recalls Jonas saying. You have a son and a daughter.

That early declaration marked, as much as any one moment could, the beginning of a journey that few have taken, one the Maineses themselves couldn’t have imagined until it was theirs. The process of remaking a family of identical twin boys into a family with one boy and one girl has been heartbreaking and harrowing and, in the end, inspiring – a lesson in the courage of a child, a child who led them, and in the transformational power of love — via redwolf.newsvine.com

Haemophilia gene therapy shows early success

Just one injection could be enough to mean people with haemophilia B no longer need medication, according to an early study in the UK and the US.

Six patients were given a virus that infects the body with the blueprints needed to produce blood-clotting proteins. Four of them could then stop taking their drugs.

Doctors said the gene therapy was potentially life-changing

Can lichen compound forestall Alzheimer’s neuron-destruction?

Research is beginning to indicate that the culprit in Alzheimer’s, Parkinson’s, and other diseases is the activity of tiny bits of misfolded amyloid-beta protein (small protein aggregates), which have a toxic, destructive effect on neurons.

Now a team of researchers in Berlin have found that orcein, historically a red lichen-derived food and fabric colour, appears to reduce the abundance of these toxic bits (called precursors because they eventually lead to large plaques). Both orcein and O4, a small blue pigment molecule similar to one in the complex 14-molecule orcein compound, bind to the pre-fibrous amyloid-beta aggregates, transforming them to large plaques which are not thought to be neurotoxic — via redwolf.newsvine.com

Organ donation overhaul pushed for NSW

The New South Wales Government has proposed a radical overhaul of organ donation rules to stop families overruling their relatives’ wishes.

The Government says it is acting because the state has the lowest organ donation rate in Australia.

More than two million NSW residents have indicated via their driver’s licence that they wish to donate at least some of their organs if they die.

But Health Minister Jillian Skinner says in many cases the families of potential donors are vetoing that decision — via redwolf.newsvine.com

Engineers pioneer use of 3D printer to create new bones

A 3D printer is being used to create bone-like material which researchers claim can be used to repair injuries.

The engineers say the substance can be added to damaged natural bone where it acts as a scaffold for new cells to grow.

It ultimately dissolves with no apparent ill-effects, the team adds.

The researchers say doctors should be able to use the process to custom-order replacement bone tissue in a few years time